Charlotte NC 704-776-4185 or

Pyroluria – Connected to ADD/ADHD, OCD, Bipolar!

Pyroluria is connected to these syndromes:

  • OCD
  • Bipolar
  • Depression
  • Autism
  • Low Motivation
  • Mood imbalances
  • Brain based behavioral issues
  • Schizophrenia
  • Anger management/Rage issues
  • Anxiety
  • Acute shyness
  • Fear of public speaking
  • Sensitivity to light, sound & food textures
  • Substance Abuse
  • MS
  • Parkinson’s
  • Crime and delinquency.

Studies show percentages for the syndromes above that suffer with Pyroluria:

  • 50% of those with autism.
  • 40% of alcoholics.
  • 70% of schizophrenics.
  • 70% of persons with depression/bipolar.
  • 30% of persons struggling with ADD/ADHD.
  • 80% of chronic Lyme disease patients.

Also, it has been found that Pyroluria is not just limited to these conditions above only.  As much as 10% of the population may have this metabolic condition and not even know it.  They may have had life long symptoms associated with it that tend to worsen with age and increased stressors; and, reaching for anti-depressants and/or anti-anxiety drugs can often exacerbate their condition.

Protracted Stress and its Connection with Pyroluria.

Most people today live under highly stressful conditions and have mood swings and bouts of depression which are thought to be related to circumstances and/or what they are dealing with on a day to day basis.  Some of us, especially, as we get older, find dealing with day to day stressors affect our mood and ability to cope with increasing difficulty.  The severity of moods and their duration can be difficult obstacles to overcome.  This often leaves a patient fatigued and more prone to viral syndromes like chronic fatigue syndrome.  Patient’s with these types of symptoms will usually visit a doctor to get a prescription for a mood enhancing drug to get some relief.  This is often a band aid treatment only and although it may temporarily reduce some of their symptoms, it can cause a completely new set of symptoms of their own and sometime make the original symptoms worse.  This type of therapy does not address the underlying issues or bring back energy levels or stop patients from getting sick with viral/bacterial infection.  We have found that these patients in their younger years may have had Pyroluria but not have shown any of the symptoms until later in life due to either acute or protracted stressors that triggered the underlying condition.

Pyroluria is it a Genetic Metabolic Condition?

Pyroluria is a genetic metabolic condition long recognized by the field of orthomolecular medicine and orthomolecular psychiatry.   Some patients have symptoms earlier on in life and are then often categorized as ADD/ADHD.  Others can develop a variety of mood and/or behavioral syndromes over time.

What Abnormalities are normally found in patients with Pyroluria?

We know that the vast majority of all these syndromes have at their root, one or more of the following abnormalities:

  • Elevated urine pyrroles
  • Abnormal copper/zinc ratios
  • Toxic metal overload
  • Poor metallothionein levels
  • Low blood copper and or high tissue copper
  • Thyroid and or adrenal hormonal imbalances
  • Low blood histamine levels
  • Poor methylation
  • Food/chemical/inhalent allergies

What tests are done to find out if a patient has Pyroluria?

A very simple and inexpensive test using blood and urine is carried out to find out whether a patient has Pyroluria.  This test is available through some of the more holistic doctors who have been through the specialized training in diagnosing and treating this condition.  The test consists of a two parts, urine and blood; the urine is collected by the patient at home and sent over night to a specialized lab, and the blood is taken by a preferred lab and also sent to the specialized lab handling the urine test.

An experienced CRA practitioner can also perform a simple in office test to see if a patient is likely to have Pyroluria before having to proceed with the lab test to confirm the diagnosis.  This is preferred by Dr. Cushing as so many conditions can have overlapping symptoms and for the lay patient would be hard to determine whether the test is necessary.

Once I am diagnosed – How is this treated?

For recovery or relief and to correct the lab based findings for a Pyroluria patient, a nutrient program will be customized to suit a patients individual chemistry.  This can be done at home with the supervision of an experienced Pyroluria doctor who can guide the patient back to optimum health.

Take the Pyroluria Challenge Test!

If you checked 15 or more of the symptoms associated with Pyroluria, it is advisable that you investigate further as to whether you have this condition.

Pyroluria Questionnaire

A questionnaire to determine if a patient is likely to have symptoms related to the condition Pyroluria.
  • Hidden
  • This field is for validation purposes and should be left unchanged.



You can learn and read more about Pyroluria from William J. Walsh, Phd.  We highly recommend his book “Nutrient Power”.


Dr. A. I. Cushing D.C.,D.Ch.,C.N.C.,F.S.A.C.


Author Info

Arthur Cushing